Gene Polymorphism of Aspirin Resistance and Individualized Treatment
10.6039/j.issn.1001-0408.2016.23.02
- VernacularTitle:阿司匹林抵抗的基因多态性及个体化治疗
- Author:
Wenxing PENG
;
Pinpin FENG
;
Xiujin SHI
;
Qi QIU
;
Haiyan DU
;
Yang LIN
- Publication Type:Journal Article
- Keywords:
Aspirin resistance;
Gene polymorphism;
Individualized treatment
- From:
China Pharmacy
2016;27(23):3172-3174
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide theoretical foundation for individualized treatment of aspirin in patients with cardiovascu-lar disease. METHODS:Domestic and foreign literatures in recent years were collected and summarized. RESULTS & CONCLU-SIONS:The gene polymorphism can significantly affect the platelet activity. GPIII a PLA2,PEAR1 and PTGS1 alleles are associat-ed with aspirin resistance,and cardiovascular events have significant difference in different genotype patients. Adjusting reasonably dosage regimen and conducting individualized treatment according to the genetic testing result and other factors can reduce aspirin resistance and the incidence of cardiovascular adverse events in the patients.
