Effects of Atorvastatin Combined with Probucol on the Vascular Elasticity in Patients with Hypertension
10.6039/j.issn.1001-0408.2016.23.26
- VernacularTitle:阿托伐他汀联合普罗布考对高血压患者血管弹性的影响
- Author:
Xiaoliu DONG
;
Shijun XU
;
Xiuqing ZHANG
;
Lixia ZHU
- Publication Type:Journal Article
- Keywords:
Atorvastatin;
Probucol;
Hypertension;
Common carotid artery;
Lower extremity artery
- From:
China Pharmacy
2016;27(23):3243-3245
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effects and safety of atorvastatin combined with probucol on the vascular elasticity in patienits with hypertension. METHODS:246 hypertensive patients were randomly divided into control group and observation group,123 cases in each group. All patients received conventional antigypertensive treatment,based on it,control group was given 10 mg Atorvastatin tablet,qd;observation group was additionally given 0.25 g Probucol tablet,qd,on the basis of control group. They were treated for 1 year. Clinical efficacy,lipid levels(total cholesterol,triglyceride,low density lipoprotein cholesterol,high density lipoprotein cholesterol),cystatin C (Cys-C),C-reactive protein (CRP),elastic parameters of common carotid artery and lower limb artery(stiffness,pressure-strain elastic modulus,compliance,augmentation index,pulse wave velocity)before and af-ter treatment in 2 groups were observed,and the incidence of adverse reactions was compared. RESULTS:Before treatment,there were no significant differences in lipid levels,Cys-C,CRP and elastic parameters of common carotid artery and lower between 2 groups (P>0.05);after treatment,the above-mentioned indexes were significantly improved,and the improvement degree in ob-servation group was superior to control group,the differences were statistically significant(P<0.05). And there were no severe ad-verse reactions during treatment in both 2 groups. CONCLUSIONS:Atorvastatin combined with probucol can improve lipid level and elasticity of common carotid artery and lower limb artery,with good safety.
