Study on Protective Effects of Li Medicine Chushi Qufeng Decoction on Arthritis Model Rats Induced by Chicken TypeⅡCollagen
10.6039/j.issn.1001-0408.2016.22.19
- VernacularTitle:黎药除湿祛风汤对鸡Ⅱ型胶原蛋白诱导关节炎模型大鼠的保护作用研究Δ
- Author:
Li ZHANG
;
Yiyun ZHANG
;
Hong FU
;
Kaiyu WANG
;
Lingfang LEI
;
Chuntao WANG
- Publication Type:Journal Article
- Keywords:
Li medicine;
Chushi qufeng decoction;
Rheumatoid arthritis;
TNF-α;
IL-1β;
Rat
- From:
China Pharmacy
2016;27(22):3088-3090
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the protective effects of Li medicine Chushi qufeng decoction on arthritis model rats. METH-ODS:60 rats were randomly divided into normal group,model group,positive group and Chushi qufeng decoction high-dose,me-dium-dose and low-dose groups [45.9,22.95,11.48 g(crude drug)/kg]. Except for normal group,those groups were given chicken type Ⅱ collagen to induce arthritis model. After modeling,normal group and model group were given normal saline intragastrical-ly,once a day,for consecutive 12 d;Chushi qufeng decoction groups were given relevant medicine intragastrically;positive group was given leflunomide 4.5 mg/kg on 1st-3rd day and 1.8 mg/kg on 4th-12th day. The degree of joint lesion in rats were scored. The degree of joint swelling was determined as well as the serum levels of TNF-α,IL-1β and type Ⅱ collagen antibody. RESULTS:Compared with normal group,arthritis index,degree of joint swelling,the serum levels of TNF-α,IL-1βand typeⅡcollagen anti-body increased significantly in model group (P<0.01). Compared with model group,pathological score of positive group and Chushi qufeng decoction high-dose group decreased significantly,and serum levels of TNF-α,IL-1β and type Ⅱ collagen antibody decreased significantly in treatment groups(P<0.05 or P<0.01). CONCLUSIONS:Li medicine Chushi qufeng decoction has cer-tain protective effect on arthritis model rats induced by chicken typeⅡcollagen.
