Preparation of Levofloxacin and Triamcinolone Acetonide Double-loaded Ophthalmic Gel
10.6039/j.issn.1001-0408.2016.22.30
- VernacularTitle:左氧氟沙星和曲安奈德双载药眼用凝胶的制备
- Author:
Lianlian FAN
;
Qingqing YANG
;
Hanlin XU
;
Peiwen ZHANG
;
Wencheng SU
;
Ya HUANG
;
Hong CHEN
- Publication Type:Journal Article
- Keywords:
Levofloxacin;
Triamcinolone acetonide;
Ophthalmic gel
- From:
China Pharmacy
2016;27(22):3125-3127
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel. METHODS:Us-ing levofloxacin hydrochloride and triamcinolone acetonide as main components,carbopol-940P as base material,HPMC K4M as tackifier,Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel was prepared. Using dissolution time as index, the contents of carbopol-940P and HPMC K4M were determined by single factor test,and dissolution time,viscosity and the con-tents of 2 main components were also determined. RESULTS:The concentrations of carbopol-940P and HPMC K4M were 0.4%and 1.2%,separately. The dissolution time was more than 24 h and viscosity was 1 142.67 Pa·s. The content of levofloxacin hydro-chloride was 97.3% of labelled amount (RSD=0.84%,n=3),and that of triamcinolone acetonide was 92.97% of labelled amount(RSD=1.32%,n=3). CONCLUSIONS:Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel has been prepared successfully.
