Study on the Extraction Technology of Compound Qima Capsules
10.6039/j.issn.1001-0408.2016.22.31
- VernacularTitle:复方芪麻胶囊的提取工艺研究
- Author:
Luolin WANG
;
Xiaobin WU
;
Rong ZHOU
;
Jianjun ZHANG
;
Liuping YUAN
- Publication Type:Journal Article
- Keywords:
Compound qima capsules;
Antihypertensive effect;
Extraction technology;
Astragaloside;
Isoflavone grape glyco-sides;
Orthogonal test
- From:
China Pharmacy
2016;27(22):3128-3131
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the extraction technology of Compound qima capsules. METHODS:With the blood pres-sure lowering of rats as index,pharmacological efficacy test was used to screen the preparation technology(A was whole herb de-coction;B was Gastrodia elata fine powder mixed with other decocted medical materials). The extraction technology was opti-mized by single factor and orthogonal test using the contents of astragaloside and isoflavone grape glycosides and the quality of sol-id as indexes,with added water,decoction time,decoction times as factors;and the verification test was carried out. RESULTS:Pharmacological efficacy test showed that antihypertensive effect of sample by technology B was superior. The optimal extraction condition of other medical materials of technology B was as follows as 12-fold water per time,decocting for 1.5 h,for 3 times. In verification test,average extraction rates of astragaloside and isoflavone grape glycosides were 64.02% and 51.97%,and average value of the quality of solid was 5.69 g(RSD≤1.92%,n=3). CONCLUSIONS:The optimized extraction technology is stable and feasible.
