Optimization of Extraction Technology for Baiyi Rectal Solution
10.6039/j.issn.1001-0408.2016.22.36
- VernacularTitle:柏薏灌肠液的提取工艺研究
- Author:
Yan LI
;
Ligang ZHAO
;
Huili WANG
;
Lina ZHENG
;
Shuyue KAN
- Publication Type:Journal Article
- Keywords:
Baiyi rectal solution;
Central composite design-response surface methodology;
Berberine hydrochloride;
Ferulic ac-id;
Extract yield
- From:
China Pharmacy
2016;27(22):3145-3147
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the extraction technology of Baiyi rectal solution. METHODS:The effects of water amount and extraction time on extraction technology were investigated by central composite design-response surface method using OD value of berberine hydrochloride and ferulic acid and the extract yield as index. Validation test was also conducted. RESULTS:The optimal extraction technology was as 11-fold water,decocting 70 min for the first time;5-fold water,decocting 30 min for the second time. In validation test,OD value of first extraction was 0.940 0,and the bias between observed and predicted values was -2.07%;that of second extraction was 0.851 8,and the bias was -2.41%. CONCLUSIONS:The extraction technology of Baiyi rectal solution is reasonable,feasible and suitable for industrial production.
