Study on Preparation and in vitro Dissolution of Ethyl Pepper Solid Dispersion
10.6039/j.issn.1001-0408.2016.22.32
- VernacularTitle:胡椒酸乙酯固体分散体的制备及体外溶出度研究
- Author:
Yanli WANG
;
Yanjie WANG
- Publication Type:Journal Article
- Keywords:
Ethyl pepper;
Solid dispersion;
PEG-6000;
Dissolution
- From:
China Pharmacy
2016;27(22):3132-3135
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the preparation and in vitro dissolution of ethyl pepper solid dispersion. METHODS:Sol-vent-melting method was adopted. Using polyethylene glycol 6000(PEG-6000)as carrier,the effects of different drug-loading ratios (1∶1,1∶5,1∶7,1∶10,1∶15,1∶18,1∶20)on the dissolution of ethyl pepper solid dispersion was invesigated. The stability of crude drug ethyl pepper at 85℃was determined. Furthermore,differential scanning calorimetry and X-ray powder diffraction meth-od were used to identify the existence of ethyl pepper in the solid dispersion. RESULTS:The dissolution of ethyl pepper could be improved by mixing ethyl pepper and PEG-6000 in a ratio of 1∶15,and the preparation was maintained stable at 85 ℃. The drugs part of ethyl pepper-PEG-6000 solid dispersions existed in the form of amorphous or molecular. CONCLUSIONS:The dissolution of ethyl pepper solid dispersion can be improved significantly by mixing ethyl pepper and PEG-6000 (1∶15),and the dispersion keeps stable at 85℃. The study can provide reference for further study of the preparation technology of ethyl pepper preparation.
