Porous titanium-niobium alloys with different porosities:biomechanical strength and cytocompatibility
10.3969/j.issn.2095-4344.2016.38.013
- VernacularTitle:不同孔隙率多孔钛铌合金的生物力学强度及细胞生物相容性
- Author:
Lei WANG
;
Qiang LI
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(38):5709-5715
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Titanium-niobium al oy holds high biomechanical strength and low elastic modulus that is close to the human cortical bone, so it has been extensively used as implant materials of dental, orthopedics and artificial hip joints. OBJECTIVE:To observe the biomechanical strength and cytocompatibility of porous titanium-niobium al oys with different porosities. METHODS:Porous titanium-niobium al oys with the porosity of 40%and 70%were prepared using powder metal urgy technology. Afterwards, the pore size, elasticity modulus and compressive strength of the two al oys were detected. Then the rabbit bone marrow mesenchymal stem cel s were seeded onto the 40%and 70%porous titanium-niobium al oys, and cel adhesion and proliferation were observed at 3, 24 and 72 hours after inoculation, respectively. RESULTS AND CONCLUSION:Pore size of porous titanium-niobium al oys with rough surface was 200-500μm, and both main pore size was 350 and 400μm, and there was three-dimensional connectivity between the pores;in the 70%group, honeycombed pores were partly fractured, and connected mutual y;pores distributed unevenly and there was little communication between the pores in the 40%group. In addition, both groups had high compressive strength and low elastic modulus, but there was no difference between the two groups. Furthermore, both two al oys promoted cel adhesion, and the number of cel adhesion in the 70%group was significantly higher than that in the 40%group (P<0.05), and extracel ular matrix could be found in the 70%group. These results show that porous titanium-niobium al oy with the porosity of 70%is significantly conducive to cel adhesion.
