Extracellular matrix-derived scaffolds for cartilage tissue engineering
10.3969/j.issn.2095-4344.2016.38.017
- VernacularTitle:细胞外基质来源支架在软骨组织工程中的应用
- Author:
Tongguang XIAO
;
Yimin ZHANG
;
Weimin GUO
;
Shuyun LIU
;
Jianhua YANG
;
Quanyi GUO
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(38):5737-5744
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:At present, a variety of extracel ular matrix-derived scaffolds have been successful y applied for cartilage tissue engineering in experiment and clinical practice. OBJECTIVE:To summarize the application and research status of extracel ular matrix-derived scaffolds in cartilage tissue engineering. METHODS:A computer-based online search in PubMed, CNKI, CqVip and WanFang databases was performed using the keywords of“tissue engineering, cartilage, extracel ular matrix, scaffolds”in English and Chinese, respectively. A total of 1 140 literatures were retrieved, and final y 65 eligible literatures were included. RESULTS AND CONCLUSION:In terms of the components, extracel ular matrix-derived scaffolds are divided into monomeric natural polymers, mixed natural polymers, natural polymers compositing with synthetic polymers as wel as acel ular extracel ular matrix-derived materials. Extracel ular matrix-derived scaffolds hold good biocompatibility and degradability, and can promote proliferation and differentiation of choncrodytes;therefore, they as good bionic scaffolds have been applied for cartilage tissue engineering in clinical practice, However, poor mechanical properties and difficulty to molding should never be ignored. Further research should focus on improving the preparation technology by combining synthetic materials with extracel ular matrix-derived scaffolds for cartilage tissue engineering.
