A long-term study of the toxicity of an Uyghur medicine, Kursi Kaknaq, on hematological parameters in rats
10.3969/j.issn.1671-7856.2016.08.009
- VernacularTitle:尿通卡克乃其片大鼠长期毒性实验的血液指标变化
- Author:
Islam RABIGUL
;
Abdugheny ABDUJILIL
;
Yingli LENG
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Kursi Kaknaq,Uyghur medicine;
Rats;
Chronic Toxicity,Blood parameters
- From:
Chinese Journal of Comparative Medicine
2016;26(8):59-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the long-term toxicity of an Uyhgur medicine, Kursi Kaknaq, on hematological parameters in the rats.Methods A total of 120 healthy Sprague-Dawley rats were randomly divided into the control, low dose (0.32 g/kg? d ), moderate dose (1.6 g/kg? d) and high dose (3.2g/kg? d) Kursi Kaknaq groups.The drug was given orally, 6 days per week for 180 days.The control group was given 0.5% sodium carboxymethyl cellulose suspension. Results No death was recorded in the rats and no obvious toxic events were observed during the experiment. Hematological parameters including RBC, HGB, MCH, MCHC, LYMP%, WBC, and PLT; biochemical parameters including ALT,AST, ALP, GLU, BUN, ALB ,TBIL, Crea, TCHO, TG, and CK; electrolyte time parameters such as K+, Na+, Cl-and prothrombin time(PT) showed statistically significant differences (P <0.05 and P <0.01), but did not show time and dose effect regularity, and no pathological significance.Conclusions No obvious toxic effects on hematological parameters are observed in the SD rats treated with Kursi Kaknaq at doses of 0.32 g, 1.6 g, or 3.2 g (crude drug) /kg? d orally administered for 180 days, indicating that this drug is safe for long-term clinical use.
