A Comparative and Experimental Study on the Treatment of Noise Induced Hearing Loss and Toxic Hearing Loss with the Stem Cells Transplantation
10.3969/j.issn.1006-7299.2016.05.014
- VernacularTitle:干细胞移植治疗噪声性和药物性聋的比较实验研究
- Author:
Hanqing ZHU
;
Junfeng ZHANG
;
Zhen XU
- Publication Type:Journal Article
- Keywords:
Cochlear stem cells;
Transplantation;
Noise induced hearing loss;
Toxic hearing loss
- From:
Journal of Audiology and Speech Pathology
2016;24(5):478-481
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effect of the cochlear stem cells transplantation in treating the noise in-duced hearing loss model and toxic hearing loss model.Methods The Experimental guinea pigs were divided into three groups:the group of the noise induced hearing loss model treated with the cochlear stem cells,the blank con-trol group of toxic hearing loss model treated with the cochlear stem cells and noise induced hearing loss model and the blank control group of toxic hearing loss model.The cochlear stem cells suspension and physiological saline were transplanted into the cochlear inner ears of the three groups,respectively.ABR detection and immunofluorescence observation were implemented three times in 7 days,28days and 56 days after the operation,respectively.Results Nestin positive cells and Myosin ⅦA positive cells were detected in both of the two models treated with cochlear stem cells,but the number of Nestin positive cells and Myosin ⅦA positive cells detected in noise induced hearing loss model was higher than that in the toxic hearing loss model.The ABR responses decreased on the noise induced hearing loss model and toxic hearing loss model treated with cochlear stem cells transplantation,but the hearing re-covery of guinea pigs in the noise induced hearing loss model was superior to the toxic hearing loss model at 28 days and 56 days after operation.Conclusion The cochlear stem cells transplantation is more effective in treating noise in-duced hearing loss than toxic hearing loss model.
