The expression levels of miR-21 and TGF-β1 in cardiac remodelin affer myocardial infarction
10.3969/j.issn.1673-4130.2016.18.004
- VernacularTitle:血浆 miR-21和 TGF-β1水平在心肌梗死后与心室重构的关系
- Author:
Fengping HE
;
Xin XU
;
Shebing ZHANG
;
Baofeng CHEN
;
Zhanzhong MA
;
Shuguo YUAN
;
Xiuyan HUANG
;
Fenglian LIU
;
Shiping FAN
;
Dongnan WU
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
cardiac remodeling;
microRNA-21;
TGF-β1
- From:
International Journal of Laboratory Medicine
2016;37(18):2513-2516
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the change of exoression level of plasma microRNA‐21(miR‐21) and TGF‐β1 in cardiac remode‐lin affer acute myocardial infarction(AMI) of the pateins .Methods 200 pateints with AMI and 100 normal controls(age ,sex matched) were enrolled .Blood samples were obtained from the normal controls and patients with AMI on the 3 days ,7 days and 14 days .Real‐time PCR was developed to detect the expression of miR‐21 and TGF‐β1 in plasma .Results The expression of miR‐21 was significantly up‐regulation in the 3 days ,7 days and 14 days in MI group than that cntrol group ,0 .74 ± 0 .21 vs .2 .62 ± 0 .23 , vs .3 .67 ± 0 .25 ,vs .4 .13 ± 0 .27 up‐regulation in the 3 days ,7 days and 14 days in MI group than that cntrol group ,0 .98 ± 0 .18 vs .2 .35 ± 0 .24 ,vs .3 .67 ± 0 .25 ,vs .4 .13 ± 0 .27 ,P<0 .05 ,respectively .The expression of miR‐21 and TGF‐β1 were up‐regulation with the change of cardiac function .Positive relationship between miRNA‐21 expression and LVDd (r=0 .757 ,P<0 .05);Positive relationship between TGF‐β1 mRNA expression and LVDd(r=0 .701 ,P<0 .05) .Conclusion The expression of miR‐21 and TGF‐β1 were up‐regulation in cardiac remodelin affer AMI of the pateins ,which involved in regulation in cardiac remodelin affer AMI .
