Van Wyk and Grumbach syndrome:A case report and literature review
10.13481/j.1671-587x.20160530
- VernacularTitle:Van Wyk-Grumbach 综合征1例报告及文献复习
- Author:
Yuan HU
;
Songshu XIAO
;
Fei ZENG
- Publication Type:Journal Article
- Keywords:
Van Wyk and Grumbach syndrome;
hypothyroidism;
ovarian cysts;
hyperprolactinaemia
- From:
Journal of Jilin University(Medicine Edition)
2016;42(5):991-994
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical materials of the patient with Van Wyk and Grumbach syndrome (VWGS),and to explore the pathogenesis,clinical characteristics,diagnosis,differential diagnosis and treatment method.Methods:The clinical data of a patient with VWGS was analyzed retrospectively.Results:The patient presented autoimmune thyroiditis, sever long-standing hypothyroidism, bilateral ovarian cysts, hyperprolactinaemia and a secondary pituitary adenoma. After thyroxine replacement treatment, the thyroid function and prolactin (PRL)level recovered to the normal levels and the ovarian cyst was shrunk within 1 month. Conclusion:The clinical manifestation of VWGS is special.And it’s easy to misdiagnose this syndrome as pituitary adenoma or ovary cyst and then operation is performed.Thyroid hormone replacement can completely resolve the symptoms and hormone abnormalities.Grasping the clinical characteristics of this syndrome and making correct diagnosis is critical to avoid unnecessary operation.
