Application of serum TK1 levels in diagnosis of non small cell lung cancer
10.3969/j.issn.1673-4130.2016.18.022
- VernacularTitle:血清 TK1水平检测在非小细胞肺癌诊断中的应用
- Author:
Bin WANG
;
Jian WANG
;
Guangsuo WANG
;
Liping TAN
;
Huakui YUE
- Publication Type:Journal Article
- Keywords:
thymidine kinase 1;
non-small cell lung cancer;
diagnosis
- From:
International Journal of Laboratory Medicine
2016;37(18):2563-2565
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the variation of serum Thymidine Kinase 1(TK1) in patients with non‐small cell lung canc‐er(NSCLC) and its clinical value .Methods Serum TK1 level of 129 patients with NSCLC and 90 healthy volunteers were measured by sensitive chemiluminescence dot‐blot assay .The serum TK1 level variation of 76 patients with NSCLC were compared before and after operation .Results Serum TK1 level of NSCLC patients were significantly higher than the level of healthy control group(P<0 .05) .Serum TK1 level in Stage Ⅲ >Stage Ⅳ >Stage Ⅰ + Ⅱ >Stage Tis ,comparison between each other was of statistical differ‐ence(P<0 .05) .The serum TK1 level of NSCLC patients at 30th day after surgery was remarkably lower than which before surger‐y(P=0 .001 ,P<0 .01) .The serum TKl level was correlated with lymphatic metastasis(P<0 .01) ,but not with other factors such as pathology types ,age ,sex and smoking .The serum TK1 measurement was high sensitivity and specificity to the diagnosis of NSCLC .Conclusion The serum TK1 level detection has important clinical significance in diagnosis and evaluation of NSCLC pa‐tients .
