Clinical Observation of Paroxetine Combined with Buspirone in the Treatment of Geriatric Depression with Anxiety
10.6039/j.issn.1001-0408.2016.21.15
- VernacularTitle:丁螺环酮联合帕罗西汀治疗老年抑郁症伴焦虑症状的临床观察
- Author:
Shuo JIANG
;
Ji ZENG
;
Yong ZHOU
- Publication Type:Journal Article
- Keywords:
Buspirone;
Paroxetine;
Geriatric depression;
Anxiety;
Efficacy;
Safety
- From:
China Pharmacy
2016;27(21):2923-2925
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of paroxetine combined with buspirone in the treatment of geriatric depression with anxiety. METHODS:78 patients with geriatric depression with anxiety were randomly divided into control group (39 cases) and observation group (39 cases). Control group received 20-40 mg Paroxetine hydrochloride tablet,within half an hour after breakfast. Observation group additionally received 5-10 mg Buspirone hydrochloride tablet for 3 times. The treatment course for both groups was 8 weeks. Clinical efficacy,HAMD,HAMA and TESS before and after 2,4 and 8 weeks of treatment in 2 groups were observed. RESULTS:The total effective rate in observation group was significantly higher than control group,the difference was statistically significant(P<0.05). HAMD after 4 and 8 weeks,HAMA after 8 weeks in control group,HAMD and HAMA after 2,4 and 8 weeks in observation group were significantly lower than before,and it gradually decreased by time pro-longed,observation group was lower than control group,the differences were statistically significant (P<0.05 or P<0.01). And there was no significant difference in the TESS rating in 2 groups before and after treatment(P>0.05). CONCLUSIONS:The effi-cacy of buspirone combined with paroxetine is superior to paroxetine alone in the treatment of geriatric depression with anxiety, with better safety.
