Efficacy and Safety of Liraglutide in the Body Mass Loss of Patients with Overweight and Obesity:A System-atic Review

VernacularTitle:利拉鲁肽降低超重和肥胖患者体质量有效性和安全性的系统评价
Author: Chunyan WEI ; Bin WU ; Na SU ; Ting XU
Publication Type:Journal Article
Keywords: Liraglutide; Overweight; Obesity; Body mass; Decrease; Meta-analysis
From: China Pharmacy 2016;27(21):2941-2944
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To systematically review the effectiveness and safety of liraglutide in the body mass loss of patients with overweight and obesity,and provide evidence-based reference for clinical treatment. METHODS:Retrieved from Medline, EMBase,CJFD,Wanfang and VIP,randomized controlled trials(RCT)about liraglutide versus placebo in the treatment of over-weight and obesity were collected. Meta-analysis was performed by using Rev Man 5.1.0 software after data extract. RESULTS:To-tally 8 RCTs were enrolled,involving 3 560 patients. Results of Meta-analysis showed weight loss degree [MD=-1.71,95%Cl (-2.25,-1.17),P<0.001] and the percentage of proportion loss more than 5% to total patients [RR=2.20,95%CI(1.83,2.63), P<0.001] in liraglutide group were significnatly more than blank control group;while the incidences of nausea,vomiting,diar-rhea,mild-to-moderate hypoglycemia and peripheral edema were significantly higher than control group. CONCLUSIONS:Liraglu-tide is effective for overweight and obesity patients. And there is mild adverse reactions but high incidence of gastrointestinal ad-verse reactions,which should be vigilant.