Effects of Different Dose Ambroxol Hydrochloride on Lung Protection of Patients in Perioperative Thoracoto-my
10.6039/j.issn.1001-0408.2016.18.10
- VernacularTitle:不同剂量盐酸氨溴索对开胸手术围术期患者肺保护作用的影响
- Author:
Kai QI
;
Hanpeng XIONG
;
Xiaoxiong LIU
;
Yan XIE
;
Guojiang XIONG
;
Wei LYU
;
Hailong DENG
- Publication Type:Journal Article
- Keywords:
Ambroxol hydrochloride;
Thoracotomy;
Perioperative;
Lung protection;
Different dose
- From:
China Pharmacy
2016;27(18):2479-2481
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of different doses ambroxol hydrochloride on lung protection of patients in perioperative thoracotomy. METHODS:60 patients in perioperative thoracotomy were randomly divided into control group(30 cas-es)and observation group(30 cases). Control group received 30 mg Ambroxol hydrochloride injection from 1 week before surgery to 1 week after surgery,adding into 100 ml 0.9% Sodium chloride injection,intravenously,twice a day. Observation group re-ceived 300 mg Ambroxol hydrochloride injection from preoperative 1 week to postoperative 1 week,adding into 100 ml 0.9%Sodi-um chloride injection,intravenously,twice a day. All patients received the second-generation cephalosporin antimicrobial drugs for anti-infection after surgery. lung surfactant-associated protein A(SP-A),intercellular adhesion molecule(ICAM-1)levels preopera-tive 1 week and postoperative 1 week,and incidence of postoperative complications in 2 groups were observed. RESULTS:Preop-erative 1 week,there were no significant differences in the SP-A and ICAM-1 in 2 groups(P>0.05). Postoperative 1 week,SP-A and ICAM-1 in control group and ICAM-1 in observation group were significantly higher than preoperative 1 week,but SP-A and ICAM-1 in observation group were lower than control group,the differences were statistically significant(P<0.05),there were no significant differences in SP-A in preoperative 1 week and postoperative 1 week(P>0.05). The incidence of postoperative compli-cations in observation group was significantly lower than control group,the difference was statistically significant(P<0.05). CON-CLUSIONS:The effect of high-doses ambroxol hydrochloride on lung protection of patients in perioperative thoracotomy is signifi-cantly superior to small dose,which can reduce the incidence of lung complications.
