Efficacy of Capecitabine Combined with Cisplatin in the Treatment of Advanced Gastric Cancer and Effect on Invasion and Metastasis of Gastric Cancer
10.6039/j.issn.1001-0408.2016.18.15
- VernacularTitle:卡培他滨联合顺铂对晚期胃癌患者疗效及胃癌细胞侵袭转移的影响
- Author:
Min LI
;
Xiangwu DING
- Publication Type:Journal Article
- Keywords:
Capecitabine;
Cisplatin;
Advanced gastric cancer;
Efficacy;
Invasion and metastasis of gastric cancer
- From:
China Pharmacy
2016;27(18):2494-2496
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy of capecitabine combined with cisplatin in the treatment of advanced gastric cancer and its effect on invasion and metastasis of gastric cancer. METHODS:94 patients with advanced gastric cancer were ran-domly divided into control group(47 cases)and observation group(47 cases). Control group received 65-75 mg/m2 Docetaxel injec-tion,d1,continuous intravenous infusion of 2 h+15-20 mg/m2 Cisplatin for injection,d1-5,continuous intravenous infusion of 2 h in the dark. Observation group received 1 000 mg/m2 Capecitabine tablet,orally,twice a day+Cisplatin for injection(the same us-age and dosage with control group). 3-week was regarded as a treatment course,and it lasted 3 courses. Clinical efficacy,matrix metalloproteinase-2(MMP-2)and MMP-9 levels were observed,6 and 12 months survival rate and incidence of adverse reactions were followed-up. RESULTS:There was no significant difference in the total effective rate in 2 groups(P>0.05). Grade 1-2 liver dysfunction,thrombocytopenia,and the incidence of nausea and vomiting in observation group were significantly lower than con-trol group,6 and 12 months survival rates were significantly higher than control group,the differences were statistically significant (P<0.05). Before treatment,There was no significant difference in MMP-2 and MMP-9 levels in 2 groups(P>0.05). After treat-ment,MMP-2 and MMP-9 levels in 2 groups were significantly lower than before,and observation group was lower than control group,the differences were statistically significant(P<0.05). CONCLUSIONS:The efficacy of capecitabine combined with cispla-tin is similar to docetaxel combined with cisplatin in the treatment of advanced gastric cancer,but docetaxel combined with cisplat-in is superior in terms of reducing MMP-2 and MMP-9 and safety.
