Effects of Risperidone Combined Ningxin Yizhi Capsule on the Cognitive Function,Neurologic Function and Living Quality of Cerebral Infarction
10.6039/j.issn.1001-0408.2016.18.12
- VernacularTitle:利培酮联合宁心益智胶囊对急性脑梗死后患者认知功能、神经功能及生活质量的影响
- Author:
Yonggui ZHANG
;
Yong DING
- Publication Type:Journal Article
- Keywords:
Risperidone;
Ningxin yizhi capsule;
Cerebral infarction;
Cognitive function;
Neurologic function;
Living quality
- From:
China Pharmacy
2016;27(18):2485-2487
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effects of risperidone combined Ningxin yizhi capsule on the cognitive function,neuro-logic function and living quality of cerebral infarction. METHODS:110 patients with cerebral infarction were randomly divided in-to control group(55 cases)and observation group(55 cases). All patients received aspirin,statins,penicillins,physical rehabilita-tion and other conventional treatment;based on it,control group orally received Risperidone tablet with initial dose of 0.5 mg, once a day,1 week later,the amount of drugs was adjusted according to the patient's tolerance and conditions,0.5 mg was in-creased every week,with maximum dose of less than 2 mg,no other antipsychotic drugs except risperidone. Observation group ad-ditionally received 0.9 g Ningxin yizhi capsule,3 times a day. The treatment course for both groups was 2 months. Montreal cogni-tive assessment (MoCA) score,neurobehavioral cognitive status tests scale (NCSE),National Institutes of Health Stroke Scale (NIHSS)score,activities of daily living scale(ADL)score and table of daily living-Barthel Index(Barthel-Index)before and af-ter treatment,and the incidence of adverse reactions in 2 groups were observed. RESULTS:Before treatment,there were no signifi-cant differences in the MoCA scores,NCSE scores,NIHSS scores,ADL scores and Barthel-Index in 2 groups (P>0.05). After treatment,the MoCA scores,NCSE scores,ADL scores and Barthel-Index in 2 groups were significantly higher than before,and observation group was higher than control group,NIHSS scores were significantly lower than before,and observation group was lower than control group,the difference was statistically significant(P<0.05). And there was no significant difference in the inci-dence of adverse reactions(P>0.05). CONCLUSIONS:Based on the conventional treatment,risperidone combined Ningxin yizhi capsule can significantly improve the cognitive function,neurologic function and living quality of cerebral infarction,with good safety.
