Relationship between WT1 gene polymorphism rs16754 and prognosis of acute myeloid leukemia:a meta-analysis

VernacularTitle:WT1基因 rs16754位点多态性与急性髓系白血病预后关系的 Meta 分析
Author: Jing XU ; Xiuhua CHEN ; Hongwei WANG
Publication Type:Journal Article
Keywords: WT1; rs16754; Leukemia,myeloid,acute; Prognosis; Meta-analysis
From: Journal of Leukemia & Lymphoma 2016;25(9):543-548
CountryChina
Language:Chinese
Abstract: Objective To analyze the relationship between WT1 gene polymorphism rs16754 and prognosis of acute myeloid leukemia (AML) by meta-analysis. Methods Studies published in PubMed, CNKI, WanFang and CBM database were searched by using the search terms 'WT1', 'Polymorphism' and 'Leukemia, Myeloid, Acute', respectively. Deadline was December 1, 2015. Results A total of 11 English articles with a total of 2 789 patients were included. Meta-analysis showed that there was no association between polymorphism rs16754 and complete remission of AML patients (RR=1.02, 95 % CI: 0.99~1.06, P=0.20), overall survival(OS) (HR=0.68, 95 % CI: 0.45~1.02, P=0.06), 5-year OS (RR=1.10, 95 % CI:0.90~1.34, P=0.37) or relapse-free survival (RFS) (HR=0.80, 95 % CI: 0.54~1.19, P=0.27). Conclusion There is no correlation between WT1 gene polymorphism rs16754 and the prognosis of AML.