The clinical characteristics and etiological analysis of diffuse alveolar hemorrhage in 138 children
10.3969/j.issn.1000-3606.2016.09.008
- VernacularTitle:138例儿童弥漫性肺泡出血临床特点及病因分析
- Author:
Wei WANG
;
Hui ZHANG
;
Xiaoyin TIAN
;
Guangli ZHANG
;
Ming CHEN
;
Qingqing MENG
;
Zhengxiu LUO
- Publication Type:Journal Article
- Keywords:
diffuse alveolar hemorrhage;
etiology;
treatment;
child
- From:
Journal of Clinical Pediatrics
2016;34(9):670-673
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical feature and common etiology of diffuse alveolar hemorrhage (DAH) in children. Methods Clinical data from 138 children with initially diagnosed DAH were retrospectively analyzed. The etiology, diagnosis, treatment, and prognosis had been summarized. Results Among 138 children, 76 were male and 62 were female. The clinical features are pallor ( 130 cases, 94 . 2%), cough ( 86 cases, 62 . 3%), fever ( 74 cases, 53 . 6%), anhelation ( 67 cases, 48 . 6%), hemoptysis ( 59 cases, 42 . 8%) and dyspnea ( 43 cases, 31 . 2%). Chest imaging changes were mainly patch shadow and ground glass shadow. Moreover, the detection rate of hemosiderin cells in sputum, gastric juice and bronchoalveolar lavage lfuid was 90 . 8%( 79/87 ). The common underlying diseases that caused DAH were idiopathic pulmonary hemosiderosis ( 65 cases), hematological system disease ( 22 cases), vascular inlfammatory diseases ( 15 cases), infectious diseases ( 14 cases) and cardiovascular disease ( 5 cases). The mortality rate in acute phase of DHA was 23 . 2%( 32/138 ). Conclusions DHA is a life-threatening clinical emergency disease, its cause was complex and diverse, and the acute mortality rate is high. Glucocorticoid is the ifrst choice of treatment for majority of patients.
