Analysis of Pathogenic Distribution and Antibiotics Use of AECOPD Patients in Respiratory Department of Our Hospital
10.6039/j.issn.1001-0408.2016.17.11
- VernacularTitle:我院呼吸内科AECOPD患者病原菌分布及抗菌药物使用分析Δ
- Author:
Sheng LU
;
Yanping XIE
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
COPD;
Acute exacerbation;
Pathogen;
Antibiotics
- From:
China Pharmacy
2016;27(17):2336-2338
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide reference for rational use of antibiotics in patients with AECOPD. METHODS:The patho-gen distribution and antibiotics use of AECOPD patients was analyzed in respiratory department of our hospital during 2014-2015. The infection site,pathogen distribution and antibiotics use(including medication purpose,drug name,usage,dosage,medication duration,route of administration,drug combination),infection and compliance were investigated and analyzed statistically. RE-SULTS:Among 967 AECOPD patients,there were 619 cases of positive sputum culture(64.01%). A total of 774 strains were iso-lated,including 542 strains of Gram-negative bacterial (70.03%) and 232 strains of Gram-positive bacterial (29.97%);most of them were Pseudomonas aeruginosa(207 strains,26.72%). 765 patients were treated with antibiotics,and utilization ratio of an-tibiotics was 79.11%. 276 cases were treated with one kinds of antibiotics (36.08%),435 treated with 2 kinds of antibiotics (56.86%)and 54 treated with 3 kinds of antibiotics and above(7.06%). Top 3 drugs in the list of frequency were Levofloxacin injection(455 cases/times,47.05%),Moxifloxacin injection(241 cases/times,24.92%)and Cefmetazole for injection(192 cas-es/times,19.86%). Top 3 drug combination regimen were Cefmetazole for injection+Levofloxacin injection (107 cases/times, 21.88%),Cefoxitin for injection+Levofloxacin injection(96 cases/times,19.63%)and Moxalactam for injection+Levofloxacin in-jection(65 cases/times,13.29%). CONCLUSIONS:Anti-infective therapy regimen of AECOPD patients should be formulated ac-cording to relevant guideline,and pathogenic factors of infection are analyzed. Great importance should be attached to reasonable, scientific,safe and standard use of antibiotics,etiological examination;pathogenic bacteria culture and drug sensitivity test should be conducted as soon as possible. So as to obtain better therapeutic efficacy and reduce the generation of drug-resistant strain.
