Analysis of Pathogen Distribution and Drug Resistance of Cerebrospinal Fluid in Pyogenic Encephalitis Pa-tients in Our Hospital during 2011-2014
10.6039/j.issn.1001-0408.2016.17.14
- VernacularTitle:我院2011－2014年化脓性脑膜炎患者脑脊液病原菌分布及耐药性分析
- Author:
Nian BAI
;
Yingying JIA
;
Yujuan GAO
- Publication Type:Journal Article
- Keywords:
Pyogenic encephalitis;
Cerebrospinal fluid;
Pathogen distribution;
Drug resistance
- From:
China Pharmacy
2016;27(17):2345-2347
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the distribution and drug resistance of pyogenic encephalitis in our hospital,and to pro-vide reference for rational use of antibiotics. METHODS:The cerebrospinal fluid pathogen of 4 255 patients with pyogenic encepha-litis in our hospital during Jan. 1st,2011-Dec. 31st,2014 were cultured and identified,and drug sensitivity test was conducted. RE-SULTS:A total of 834 pathogens were isolated with positive detection rate of 19.6%,including 576 strains of gram-positive bacte-ria,accounting for 69.1%;255 strains of gram-negative bacteria,accounting for 30.6%;3 strains of fungi,accounting for 0.4%. Top 3 gram-positive bacteria were Coagulase-negative staphylococci(436 strains),Staphylococcus aureus(56 strains)and Entero-coccus (29 strains). Top 3 gram-negative bacteria were Klebsiella pneumoniae (46 strains),Acinetobacter baumannii (38 strains) and Escherichia coli(31 strains). Top 3 departments were neurosurgery department(506 strains),ICU(169 strains)and severe re-spiratory disease department (64 strains). Results of drug sensitivity test showed that no drug-resistant Staphylococcus and Entero-coccus strains to vancomycin,teicoplanin and miuocycline was found;nonfermenting Gram-negative bacilli showed low resistant to minocycline. CONCLUSIONS:Gram-positive bacteria dominates the detection rate of cerebrospinal fluid of pyogenic encephalitis patients;drug resistance of various pathogens is serious and clinicians should choose antibiotics based on drug sensitivity.
