Clinical Observation of Chaihu Shugan Powder Combined with Clonazepam in the Treatment of Liver Qi Stagnation Type Anxiety
10.6039/j.issn.1001-0408.2016.17.35
- VernacularTitle:柴胡舒肝散联合氯硝西泮治疗肝气郁结型焦虑症的临床观察
- Author:
Hongyan CHENG
;
Yan MEI
;
Hongwei DU
- Publication Type:Journal Article
- Keywords:
Chaihu shugan powder;
Clonazepam;
Liver qi stagnation anxiety;
Clinical efficacy;
Safety
- From:
China Pharmacy
2016;27(17):2407-2409
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe clinical efficacy and safety of Chaihu shugan powder combined with clonazepam in the treatment of liver qi stagnation type anxiety. METHODS:96 patients with liver qi stagnation type anxiety were randomly divided in-to observation group and control group,with 48 cases in each group. Control group was given Clonazepam tablet with initial dose of 0.5 mg,increasing to 4.0 mg gradually,tid;observation group was additionally given Chaihu shugan powder 300 ml,bid,on the basis of control group. Both groups were treated for 6 weeks. Clinical efficacy of 2 groups were observed,and HAMA and SAS were observed before and after treatment;the incidence of ADR were compared between 2 groups. RESULTS:The total effective rate of observation group(97.92%)was significantly higher than that of control group(83.33%),with statistical significance(P<0.05). There was no statistical significance in HAMA and SAS between 2 groups before treatment(P>0.05);HAMA and SAS of 2 groups decreased significantly 1,3 and 6 weeks after treatment,and the observation group was lower than the control group, with statistical significance(P<0.05). There was no statistical significance in the incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:Chaihu shugan powder combined with clonazepam is effective,improve patient anxiety and safe in the treatment of liver qi stagnation type anxiety.
