Recent progress for HBV infection model in vitro and in vivo
10.3969/j.issn.1671-7856.2016.09.017
- VernacularTitle:乙肝病毒体内外感染模型研究进展
- Author:
Guili XU
;
Xin GAO
;
Zhengzhu LIU
;
Yuanfang GONG
;
Haifeng SONG
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Cell model;
Animal model
- From:
Chinese Journal of Comparative Medicine
2016;26(9):93-98
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus ( HBV) is an important pathogen threatening to human health. Up to date, various of cell infection models and animal models for HBV and the host are widely used in the exploring research of infection mechanism, new drug development and effective therapeutic method for HBV. However, these models have some defects, such as low infection rate, rather short infective stage, and comparatively large species differences with human, and so on. Among them, the biggest problem is that these models cannot completely simulate HBV infection process and pathological changes naturally occurred in human. Herein, the major HBV infection models developed in the past fifteen years, as well as the latest research progress, are presented as a brief review, to provide a reference for constructing novel HBV infection models in the future.
