Formula Screening and in vitro Drug Release of Tegafur Thermo-sensitive Gel for Intratumor Injection
- VernacularTitle:瘤内注射用替加氟温敏凝胶的处方筛选及体外释放研究
- Author:
Jingjing SHEN
;
Aiping DENG
;
Hong LIU
;
Yi WANG
;
Jue LIU
- Publication Type:Journal Article
- Keywords:
Intratumoral injection;
Tegafur;
Temperature-sensitive gel;
Formula screening;
In vitro release rate
- From:
China Pharmacist
2016;19(9):1656-1659
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To screen the best formula of tegafur temperature-sensitive gel for intratumor injection and investigate the in vitro drug release behavior. Methods:The drug dose was determined by cytotoxicity experiment. The thermo-sensitive gel was prepared with PLGA-PEG-PLGA and HPMC as the matrix. With the in vitro release as the index, the effects of PLGA-PEG-PLGA and HPMC at different concentrations on gel were investigated. The gelation temperature, viscosity and pH were detected. Results:The best formula was as follows:25% PLGA-PEG-PLGA, 1% HPMC, and tegafur dose of 1 mg·ml-1 . The average gelation temperature was 36. 7℃, the average viscosity was 7550 mPa·s, and the average pH was 7. 2. Conclusion:Tegafur thermo-sensitive gel for intratumor in-jection shows temperature sensitivity and obvious sustained-release property, which provides experimental basis for the further clinical research.
