Curative Effect of Salvia Miltiorrhiza Phenolic Acid Combined with Ulinastatin on Acute Respiratory Dis-tress Syndrome and Its Effect on Biochemical Indices of Patients
- VernacularTitle:丹参多酚酸联合乌司他丁治疗急性呼吸窘迫综合征的疗效及对患者生化指标的影响
- Author:
Yongli QIAO
- Publication Type:Journal Article
- Keywords:
Salvia miltiorrhiza phenolic acid injection;
Acute respiratory distress syndrome;
Ulinastatin;
Curative effect;
Bio-chemical index
- From:
China Pharmacist
2016;19(9):1713-1715
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of salvia miltiorrhiza phenolic acid combined with ulinastatin in the treatment of a-cute respiratory distress syndrome ( ARDS) and the influence on the biochemical parameters of patients. Methods:Totally 86 cases of ARDS were selected and randomly divided into the observation group (43 cases) and the control group (43 cases) according to the random number table. The control group was treated with the routine treatment, and the observation group was treated with salvia milti-orrhiza phenolic and injection additionally. The treatment course was 10 days. The total effective rate, RR and HR, PaO2 , SaO2 and PaCO2 , IL-6, TNF-αand CRP levels and the incidence of adverse reactions were compared between the groups. Results:The total ef-fective rate of the observation group(86. 05%) was higher than that of the control group (67. 44%, P<0. 05). RR and HR in the two groups were significantly decreased after the treatment (P<0. 05), and those in the observation group were significantly lower than those in the control group (P<0. 05). After the treatment, PaO2and SaO2 were significantly increased in the two groups, and PaCO2 was significantly decreased (P<0. 05), and SaO2 and PaO2 in the observation group were higher than those in the control group, and PaCO2 was lower than that in the control group (P<0. 05). The plasma levels of IL-6, TNF-α and CRP were significantly decreased in the two groups after the treatment (P<0. 05), and those in the observation group were lower than those in the control group (P<0. 05). No serious adverse drug reactions were found in the two groups. Conclusion:The effect of salvia miltiorrhiza phenolic acid in the treatment of ARDS is significant, and it can significantly improve heart rate, respiratory rate, blood gas and serum inflammatory factors, which is worthy of promoted clinical application.
