Clinical Efficacy of Magnesium Isoglycyrrhizinate Combined with Routine Therapy in the Treatment of Pa-tients after Closed Abdominal Trauma Complicated with Liver Damage
- VernacularTitle:异甘草酸镁联合常规治疗闭合性腹外伤术后合并肝功能损害疗效观察
- Author:
Xinmei WU
;
Wei ZHU
;
Wei LUO
;
Zhenyu LUO
- Publication Type:Journal Article
- Keywords:
Magnesium isoglycyrrhizinate;
Closed abdominal injury;
Liver function damage;
Efficacy;
Safety
- From:
China Pharmacist
2016;19(9):1719-1721
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of magnesium isoglycyrrhizinate ( MgIG) in the treatment of patients with liver damage after closed abdominal trauma. Methods:Totally 84 cases of patients with closed abdominal trauma were randomly divided into the observation group (n=42) and the control group (n=42) according to the random number table. The control group was given the conventional treatment, while the observation group was treated with MgIG additionally. The treatment course was 14d. The clinical efficacy and the level changes of albumin, prealbumin, TBiL, AST and ALT before and after the treatment in the two groups were stud-ied and compared, and the adverse reactions during the treatment course were also compared between the groups. Results: The total effective rate of the observation group (90. 48%) was significantly higher than that of the control group(69. 05%, P<0. 05). After the treatment, the plasma albumin and prealbumin levels in both groups were significantly increased (P<0. 05), and those in the ob-servation group were significantly higher than those in the control group (P<0. 05). The serum TBiL, AST and ALT levels in both groups were significantly decreased after the treatment (P<0. 05), and those in the observation group were significantly lower than those in the control group (P<0. 05). There was no serious adverse reaction during the treatment course in both groups. Conclusion:MgIG in the treatment of liver damage after closed abdominal trauma shows notable effect, which can improve liver function obviously with high safety and reliability.
