Progress in remodeling and spacing factor-1 in human malignant tumors

VernacularTitle:染色质重塑因子1在人类恶性肿瘤中的研究进展
Author: Xitao CHEN ; Qingchang LI
Publication Type:Journal Article
Keywords: Remodeling and spacing factor-1; Neoplasms; Prognosis
From: Cancer Research and Clinic 2016;28(9):641-645
CountryChina
Language:Chinese
Abstract: Remodeling and spacing factor-1 (Rsf-1), firstly discovered in 1998 and located in the nucleus, is one of the most commonly amplified gene and its protein molecular weight is about 240 ×103. The interaction between Rsf-1 and human sucrose non-fermenting protein 2 homologue (hSNF2H) changes the cell growth signals and environment, which is inclined to cause the cells loss of the normal regulation, leading to the abnormal proliferation and occurrence of tumors. Recent study has shown that Rsf-1 is closely related to the prognosis of a lot of human malignancies, such as genitourinary system tumors, gastrointestinal tumors, head and neck cancer, non-small cell lung cancer and glioma.