Progress in opioid receptor and opioids for the treatment of cancer pain

VernacularTitle:阿片受体及阿片类药物治疗癌痛的研究进展
Author: Dongdong TIAN ; Lixia NIE ; Baozhong YANG ; Xuping GAO
Publication Type:Journal Article
Keywords: Cancer pain; Receptors,opioid; Morphine; Oxycodone
From: Cancer Research and Clinic 2016;28(9):645-648
CountryChina
Language:Chinese
Abstract: Cancer pain is the most important factor affecting the cancer patients' quality of life, and the approach to relieve and control cancer pain is becoming the focus. Pain mechanism research can offer solutions to pain treatment, such as blocking the happening and conduction of analgesia. The earliest μ, κ, σopioid receptors were found in the research of morphine and opioid peptides, especially μ receptor's leading role in pain treatment. Currently, μ opioid agonist is basically used in clinical pain treatment. Morphine, the third level drug, is still the classic pain therapy drugs. Novel drugs such as fentanyl transdermal and controlled-release oxycodone provide new ideas for the pain ease. Opioid combined with non-opioid drugs, the change of opioid drugs delivery way and joint application of controlled release drug and relievers, have dramatically reduced opioid drugs' side effects.