Effects of OPRM1 A118G Gene Polymorphism on the Dosage of Opioids in Chinese Han Population Pa-tients with Cancer Pain
10.6039/j.issn.1001-0408.2016.20.01
- VernacularTitle:OPRM1 A118G多态性对我国汉族癌痛患者阿片类药物使用剂量的影响
- Author:
Ying LI
;
Feixue WU
;
Li SUN
;
Xiang LI
;
Yongzhong WANG
- Publication Type:Journal Article
- Keywords:
OPRM1;
Gene polymorphism;
Cancer pain;
Opioids;
Dosage;
Han population
- From:
China Pharmacy
2016;27(20):2737-2739
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide reference for the individualized treatment of opioid drugs by investigating the effects of OPRM1 A118G gene polymorphism on opioids dosage in Chinese Han Population patients with cancer pain. METHODS:66 Chi-nese Han Population patients with medium and severe cancer pain were selected from a third grade class A hospital. Using fluores-cence in-situ hybridization,OPRM1 A118G genotypes were detected to compare the opioids dosage of different genotype in pa-tients with cancer pain. RESULTS:Among 66 patients,distribution frequency of AA,AG and GG genotype were 36.36%, 53.03% and 10.61%,respectively;those of A and G allele were 62.88% and 37.12%;the daily dosage of opioids in AA,AG, GG genotype patients respectively were(21.67±13.41),(42.00±32.18)and(87.14±73.65)mg,with statistical significance(P<0.001). Among 39 patients receiving opioids for the first time,the dosage of 6 AA genotype patients and 15 AG genotype patients had been adjusted,with statistical significance(P=0.026). After adjusting dosage,daily dosage of AA genotype and AG genotype patients were (16.11 ± 9.16) and(28.57 ± 18.52)mg,with statistical significance (P=0.011). CONCLUSIONS:OPRM1 A118G genotype can influence the dosage of opioid in Chinese Han Population patients with cancer pain,and gene polymorphism can be used as evidence for dosage guide of opioids.
