Clinical Observation of Biyuan Tongqiao Granule Combined with Triamcinolone Acetonide Spray in the Treatment of Chronic Rhinosinusitis
10.6039/j.issn.1001-0408.2016.20.18
- VernacularTitle:鼻渊通窍颗粒联合曲安奈德鼻喷雾剂治疗慢性鼻-鼻窦炎的临床观察Δ
- Author:
Jun YONG
;
Yongfeng WANG
- Publication Type:Journal Article
- Keywords:
Biyuan tongqiao granule;
Triamcinolone acetonide spray;
Chronic rhinosinusitis;
Therapeutic efficacy
- From:
China Pharmacy
2016;27(20):2795-2797
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the clinical efficacy and safety of Biyuan tongqiao granule combined with Triamcinolone acetonide spray in the treatment of chronic rhinosinusitis. METHODS:120 patients with chronic rhinosinusitis were randomly divid-ed into observation group and control group,with 60 cases in each group. Control group was given Triamcinolone acetonide spray 220 μg,qd,in first week,decreasing to 110 μg,qd;observation group was additionally given Biyuan tongqiao granule 15 g,tid, on the basis of control group. Both groups were treated continuously for 10 weeks. The clinical efficacy of 2 groups were observed as well as the levels of MTR,IL-5 and IL-8,SNOT-20 score,VAS score and Lund-Mackey sinus CT score before and after treat-ment. The incidence of ADR was compared between 2 groups. RESULTS:Total effective rate of observation group was 93.3%, which was significantly higher 85.0% of control group,with statistical significance(P<0.05). There was no statistical significance in IL-5,IL-8,MTR,SNOT-20 score,VAS score and Lund-Mackey sinus CT score between 2 groups before treatment(P>0.05). IL-5 and IL-8 levels of 2 groups decreased significantly,while MTR,SNOT-20 score,VAS score and Lund-Mackey sinus CT score were decreased significantly;the observation group was better than the control group,with statistical significance(P<0.05). There was no statistical significance in the incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:Biyuan tongqiao gran-ule combined with Triamcinolone acetonide spray is effective in the treatment of chronic rhinosinusitis,and can effectively improve the quality of life and relieve clinical symptom with good safety.
