Action Mechanism of TLR2/4-NF-κB Signal Pathway during the Attack of Gouty Arthritis
- VernacularTitle:“TLR2/4-NF-κB”信号转导通路在痛风性关节炎发病中的作用机制
- Author:
Qi ZHOU
;
Shumin LIU
;
Wanru DONG
- Publication Type:Journal Article
- Keywords:
IL-1β;
NF-κB;
TLR2;
TLR4;
Gouty arthritis
- From:
China Pharmacist
2016;19(9):1733-1736
- CountryChina
- Language:Chinese
-
Abstract:
Toll-like receptors ( TLRs) are pattern recognition receptors, which exist in both cell membrane and cytoplasm, and participate in inflammatory reactions. Some studies have shown that TLR2/4-NF-κB signal pathways mediated by TLR2 and TLR4 could regulate the production of inflammatory factor IL-1β, which played an important role in the attack of gouty arthritis. The article focused on the pathogenesis of gouty arthritis, discussed the structure and distribution of TLRs, the ligands and its mediated signal pathways, the validity in the treatment of gouty arthritis using the signal pathways as the target points and the relationship between the signal pathways and gouty arthritis, and reviewed the research progress in Chinese medicines using the signal pathways as the guidance.
