Research Progress in Experimental Methods for the Evaluation of Adhesion Property of Bioadhesive Drug Delivery Systems in vitro
- VernacularTitle:生物黏附给药系统黏附性能的体外评价方法的研究进展
- Author:
Lin LV
;
Guojie WANG
;
Xiaoming HE
;
Qing DU
;
Yunjie DANG
- Publication Type:Journal Article
- Keywords:
Bioadhesive drug delivery systems;
Adhesion property;
In vitro evaluation
- From:
China Pharmacist
2016;19(9):1752-1755
- CountryChina
- Language:Chinese
-
Abstract:
Bioadhesive delivery systems with sustained release characteristics can promote the absorption and increase the bio-availability of drugs by prolonging the residence time on the applied site. The evaluation of adhesion property of bioadhesive drug deliv-ery systems is important because the sustained release effect and the absorption are closely related with the adhesion. The methods for the evaluation of the adhesive properties of bioadhesive drug delivery systems in vitro were summarized in the article, including determi-ning the minimum peel force, measuring the residues on mucosa surface, determining the retention time on mucosal surface, measuring the swelling and the viscosity of fluid and so on, and the operation of some methods were described simply as well.
