Study on Compatibility Stability of Flurbiprofen Axetil Lipid Microspheres Injection
- VernacularTitle:氟比洛芬酯脂微球注射液的配伍稳定性考察
- Author:
Yuting ZHU
;
Jianjun NI
;
Xinjun CAI
;
Yingying XU
;
Feng ZHOU
- Publication Type:Journal Article
- Keywords:
Flurbiprofen axetil lipid microspheres injection;
Compatibility;
Stability
- From:
China Pharmacist
2016;19(9):1781-1782
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the stability of flurbiprofen axetil lipid microspheres injection combined with 0. 9% sodium chloride injection or 5% dextrose injection, and provide theoretical basis for the clinical application. Methods:The content changes of flurbiprofen axetil in the mixture of flurbiprofen axetil lipid microspheres injection and 0. 9% sodium chloride injection or 5% dextrose injection were determined in 5 h at 25℃ away from light, and the changes in the appearance and particle size of flurbiprofen axetil lip-id microspheres were investigated. The changes in the appearance and particle size of flurbiprofen axetil lipid microspheres in the mix-ture of flurbiprofen axetil lipid microspheres injection and 0. 9% sodium chloride injection before and after freezing and thawing were also investigated. Results:The appearance, particle size and content had no significant changes in all mixtures in 5 h at 25 ℃ away from light. The appearance and particle size of flurbiprofen axetil lipid microspheres in the mixture before and after freezing and thawing had no significant changes as well. Conclusion:The mixture of flurbiprofen axetil lipid microspheres injection and 0. 9% sodium chlo-ride injection or 5% dextrose injection is stable in 5 h away from light.
