Investigation of Osmotic Pressure of Citicoline Sodium Injection
- VernacularTitle:胞磷胆碱钠注射剂渗透压考察
- Author:
Xiaoyan HE
;
Zhenyu PAN
;
Jing XIAO
- Publication Type:Journal Article
- Keywords:
Citicoline sodium injection;
Osmotic pressure
- From:
China Pharmacist
2016;19(9):1797-1799
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the osmotic pressure of citicoline sodium injection from different manufacturers to provide experi-mental basis for improving the national standard of the product. Methods:The cryoscopic method was used to detect the osmotic pres-sure of 479 batches of citicoline sodium injection from 45 pharmaceutical factories. Results:The osmotic pressure of citicoline sodium injection was within the range of 359-692 mOsmol · kg-1 , that of citicoline sodium for injection was within the range of 401-1408 mOsmol·kg-1 , and that of citicoline sodium chloride injection was within the range of 278-299 mOsmol·kg-1 . Conclusion:The os-motic pressure of citicoline sodium injection and citicoline sodium for injection from different manufacturers is obviously different. It is necessary to detect osmotic pressure in the quality standard in order to evaluate the quality of preparation process.
