Analysis of Distribution and Drug Resistance of Pathogens in Patients with Hospital Acquired Pneumonia from Neurosurgery Department of Our Hospital during 2011-2015
10.6039/j.issn.1001-0408.2016.20.11
- VernacularTitle:2011－2015年我院神经外科医院获得性肺炎患者的病原菌分布及耐药性分析Δ
- Author:
Shan ZHANG
;
Weimin LI
;
Mei ZHANG
- Publication Type:Journal Article
- Keywords:
Hospital acquired pneumonia;
Neurosurgery department;
Pathogens;
Distribution;
Drug resistance
- From:
China Pharmacy
2016;27(20):2771-2773
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the distribution and drug resistance of pathogens in patients with hospital-acquired pneumo-nia(HAP)from neurosurgery department of the First Affiliated Hospital of Xinjiang Medical University(called“our hospital”for short),so as to provide reference for clinical use of antibiotics in the clinic. METHODS:The pathogen culture and drug sensitivity test of 652 HAP patients were analyzed retrospectively in neurosurgery department of our hospital during May 2011 to May 2015. RESULTS:Of 652 cases,pathogens were detected in 608 cases,with positive rate of 93.3%. Among 608 strains of pathogen, there were 443 strains of Gram-negative bacteria(71.2%)as Klebsiella pneumonia,Pseudomonas aeruginosa and Escherichia co-li;108 strains of Gram-positive bacteria (17.8%) as Staphylococcus aureus and Streptococcus pneumoniae;67 strains of fungus (11.0%)as Candida albicans. There were 67 strains of ESBLs K. pneumonia,43 strains of ESBLs E. coli and 8 strains of methicil-lin-resistant coagulase negative Staphylococci. The drugs sensitive to Gram-negative bacteria included imipenem,piperacillin sodi-um and tazobactam sodium,cefepime,etc.;those sensitive to Gram-positive bacteria included vancomycin,etc. CONCLUSIONS:Main pathogen of HAP patients in neurosurgery department of our hospital are Gram-negative bacteria,and they were highly resis-tant to antibiotics;the highly sensitive drugs to HAP include imipenem and vancomycin,etc.;the antibiotics should be used ratio-nally according to etiological analysis.
