Clinical Observation of Mycophenolate Mofetil Combined with Glucocorticoid in the Treatment of Refrac-tory Idiopathic Thrombocytopenic Purpura
10.6039/j.issn.1001-0408.2016.20.26
- VernacularTitle:吗替麦考酚酯联合糖皮质激素治疗难治性特发性血小板减少性紫癜的临床观察
- Author:
Yun LI
;
Huibing DANG
- Publication Type:Journal Article
- Keywords:
Mycophenolate mofetil;
Glucocorticoid;
Refractory idiopathic thrombocytopenic purpura
- From:
China Pharmacy
2016;27(20):2819-2821
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the therapeutic efficacy and safety of mycophenolate mofetil combined with glucocorti-coid in the treatment of refractory idiopathic thrombocytopenic purpura (ITP). METHODS:134 cases of refractory ITP were ran-domly divided into observation group and control group,with 67 cases in each group. Control group was given Prednison acetate tablet orally,0.5 mg/kg each day,morning and evening. Observation group was additionally given Mycophenolate mofetil dispers-ible tablet,1 g/time,bid. A treatment course lasted for 3 weeks,and both groups received 3-5 courses of treatment. Clinical effica-cy of 2 groups were compared as well as the change of PLT before and after treatment,satisfaction degree of treatment and adverse event. RESULTS:The total effective rate of observation group (91.04%) was significantly higher than that of control group (74.63%),with statistical significance(P<0.05);PLT of observation group was significantly greater than that of control group 7, 14 and 21 d after treatment,with statistical significance(P<0.05);total satisfactory degree of observation group was significantly higher than that of control group (89.55% vs. 80.60%),and the incidence of adverse event was significantly lower than control group(2.99% vs. 10.44%),with statistical significance(P<0.05). CONCLUSIONS:Mycophenolate mofetil combined with glu-cocorticoid can improve clinical efficacy,PLT and satisfactory degree significantly in the treatment of refractory ITP with good safety.
