Protective Effects of Tongmaitang Yanming Capsules on Retinal Damage of Aged Rats
10.6039/j.issn.1001-0408.2016.16.12
- VernacularTitle:通脉糖眼明胶囊对老龄大鼠视网膜损伤的保护作用Δ
- Author:
Chunmei PU
;
Xiangling QU
;
Xunrong ZHOU
- Publication Type:Journal Article
- Keywords:
Tongmaitang yanming capsules;
Aged rat;
Retina damage;
Antioxidant activity;
Retinal neuron
- From:
China Pharmacy
2016;27(16):2200-2202
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the protective effects of Tongmaitang yanming capsules on retinal damage of aged rats. METHODS:Aged rats(aged 24 months)were randomly divided into Tongmaitang yanming capsule high-dose,medium-dose and low-dose groups (1.750,0.875,0.378 g/kg),positive control drug group (Calcium dobesilate capsules,0.175 g/kg) and model group,with 10 rats in each group. They were given relevant medicine intragastrically once a day for consecutive 90 days. At the end of the 90th day,another 10 rats aged 1.5 months were included into blank control group. After medication,60 rats were provid-ed with water but no food for 12 hours. Blood sample was collected from femoral,and the serum levels of GSH-Px,GSH,SOD and MDA was determined,respectively;right eyes were sampled,pathological change of retina was observed by HE staining and the number of retinal cell layer (RCL) neurons was counted. RESULTS:Compared with blank control group,serum levels of GSH-Px,GSH and SOD decreased in model group,while MDA level increased;the number of RCL neurons was (59 ± 4)% of blank control group (P<0.05 or P<0.01),and retina damage was found. Compared with model group,the serum levels of GSH-Px,GSH and SOD increased in positive control drug group and Tongmaitang yanming capsule groups,while MDA level de-creased;the number of RCL neurons in those groups were (98 ± 7)%,(69 ± 5)%,(78 ± 7)% and (95 ± 6)% of blank control group,respectively (P<0.05 or P<0.01);retina damage was relieved. CONCLUSIONS:Tongmaitang yanming capsules can in-hibit aging-induced lipid peroxidation of rat retina,prevent the progressive loss of retina neurons and protect aging-induced retina damage of rats.
