Optimization of the Extraction Technology of Bushen Huoxue Capsules by Central Composite Design-re-sponse Surface Method
10.6039/j.issn.1001-0408.2016.16.34
- VernacularTitle:星点设计-响应面法优化补肾活血胶囊提取工艺
- Author:
Jia YIN
;
Jian YIN
;
Yan ZHU
;
Bingqi XING
;
Chunsheng FU
- Publication Type:Journal Article
- Keywords:
Bushen huoxue capsules;
Central composite design-response surface method;
Extraction technology;
Icariin;
Salvi-anolic acid B
- From:
China Pharmacy
2016;27(16):2276-2278
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the extraction technology of Bushen huoxue capsules. METHODS:Central composite de-sign-response surface method was used to optimize the extraction technology with the amount of water and boiling time as main fac-tors using normalized value of the contents of icariin and salvianolic acid B,the yield of dry extract as index. Validation test was al-so conducted. RESULTS:The optimal extraction technology was as follows as 15-fold water,reflux extracting for 75 min,extract-ing for 2 times. The deviation of measured value and predicted value was 0.000 3% in validation test. CONCLUSIONS:The cen-tral composite design-response surface method can be used to optimize the extraction technology of Bushen huoxue capsules with good prediction,and the technology is simple and stable.
