Effects of Calcitriol on Related Indicators in Patients with Chronic Renal Failure
10.6039/j.issn.1001-0408.2016.15.14
- VernacularTitle:骨化三醇对慢性肾功能衰竭患者相关指标的影响
- Author:
Jianzhong LU
;
Lan TAO
;
Xinge XU
;
Xiaofen WU
;
Haiyan WANG
- Publication Type:Journal Article
- Keywords:
Calcitriol;
Chronic renal failure;
Micro-inflammatory state;
Hemoglobin;
Alkaline phosphatase;
erythrocyte;
Re-nal function
- From:
China Pharmacy
2016;27(15):2056-2058
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of calcitriol on related indicators in patients with chronic renal failure (CRF). METHODS:114 patients with CRF were randomly divided into observation group(57 cases)and control group(57 cas-es). Control group was given high-quality low-protein and low phosphorus diet,if necessary,phosphate binders,Calcium D3 tablet and other conventional treatment;observation group was additionally given 0.25 μg Calcitriol soft capsule,once a day. The treat-ment course for both groups was 8 weeks. Serum levels of inflammatory factors,alkaline phosphatase,hemoglobin,erythrocyte, serum creatinine and urea nitrogen levels and adverse reactions in 2 groups before and after treatment were observed. RESULTS:Before treatment,there were no significant differences in the serum levels of inflammatory factors,alkaline phosphatase,hemoglobin, erythrocyte,senum creatininine and ureanitrogen between 2 groups(P>0.05). After treatment,serum inflammatory factors,alkaline phosphatase,serum creatinine and urea nitrogen levels in 2 groups were significantly shorter than before,and observation group was lower than control group,the differences were statistically significant (P<0.05);there were no significant differences in the hemoglobin and erythrocyte levels before and after treatment between 2 groups(P>0.05). And there was no obvious adverse reac-tions between 2 groups during treatment. CONCLUSIONS:Based on the conventional treatment,calcitriol can reduce the levels of serum inflammatory factors and improve micro-inflammatory state and renal function in patients with CRF.
