Effect of Ticagrelor versus Prasugrel on Platelet Reactivity:A Meta-analysis
10.6039/j.issn.1001-0408.2016.15.23
- VernacularTitle:替格瑞洛对比普拉格雷对血小板反应性影响的Meta分析
- Author:
Yumeng WU
;
Lichun CHENG
;
Jing LIANG
;
Lilong LIU
;
Xiangju SUN
;
Jia SONG
;
Yubo WU
- Publication Type:Journal Article
- Keywords:
Ticagrelor;
Prasugrel;
Platelet reactivity;
Meta-analysis
- From:
China Pharmacy
2016;27(15):2083-2086
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review the effect of ticagrelor versus prasugrel on platelet reactivity,and provide evi-dence-based reference for clinical treatment. METHODS:Retrieved from PubMed,CJFD and Wanfang Database,randomized con-trolled trials(RCT)about the effect of ticagrelor versus prasugrel on platelet reactivity were collected. Meta-analysis was performed by using Rev Man software after data extract and quality evaluation by Cochrane 5.1.0. RESULTS:Totally 17 RCTs were enrolled,involv-ing 2 757 patients. Results of Meta-analysis showed,regardless of Verity Now(VN)detection method [MD=15.43,95%CI(-0.39, 31.25),P=0.06] or vasodilator stimulus phosphoprotein(VASP)detection method [MD=-3.04,95%CI(-8.98,2.90),P=0.32], ticagrelor and prasugrel had the same effects on platelet reactivity under loading dose,the differences were not statistically significant;regardless of VN detection method [MD=-48.94,95%CI(-58.04,-39.84),P<0.001] or VASP detection method [MD=-14.32, 95%CI(-20.45,-8.20),P<0.001],the effects of ticagrelor were better than prasugrel on platelet reactivity under maintenance dose,the differences were statistically significant. CONCLUSIONS:At the loading dose,there was no difference between ticagrelor and prasugrel,but ticagrelor has more benefits than prasugrel under maintenance dose.
