Study on the Pharmacodynamic Comparison of Active Part in Crude Atractylodes lancea and Atractylodes lancea Fried with Bran
10.6039/j.issn.1001-0408.2016.10.04
- VernacularTitle:苍术麸炒前后活性部位药效比较研究
- Author:
Xue PANG
;
Yuqiang LIU
;
Xiaodan LIU
;
Meiyu GUAN
;
Qian CAI
- Publication Type:Journal Article
- Keywords:
Atractylodes lancea;
Fired with bran;
Rats;
Spleen and stomach damp obstruction model;
Active part;
Amylase;
D-xylose;
Gastrin;
Vasoactive intestinal peptide;
NO;
Pharmacodynamics
- From:
China Pharmacy
2016;27(10):1308-1311
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the pharmacodynamics of active parts in crude Atractylodes lancea and A. lancea fired with bran. METHODS:170 rats were randomly divided into 17 groups,including blank control group,spleen and stomach damp obstruction model group,volatile oil of crude A. lancea and A. lancea fired with bran high-dose and low-dose(0.747,0.083 mg/ml by the concentration of crude medicinal materials,similarly hereinafter)groups,solvent control 2% polysorbate 80 group,dichlo-romethane extract of crude A. lancea and A. lancea fired with bran high-dose and low-dose groups,solvent control 1‰ polysorbate 80 group,n-butyl alcohol extract of crude A. lancea and A. lancea fired with bran high-dose and low-dose groups,solvent control stomach damp obstruction model distilled water control group. Except blank control group,other 16 groups were given Sennae foli-um decoction ig for 14 d to induce spleen and stomach damp obstruction model,and then received relevant medicine or solvent ig once a day for consecutive 7 d. Body weight of rats were determined before and after medication,and the serum levels of amylase, D-xylose,gastrin,vasoactive intestinal peptide and NO were determined after medication. RESULTS:Compared with spleen and stomach damp obstruction model group,the body weight and serum levels of gastrin,amylase and D-xylose increased significantly in rats of active part in A. lancea fired with bran groups(P<0.05),while vasoactive intestinal peptide and NO decreased signifi-cantly(P<0.05). Compared active part in crude A. lancea group,except the body weight,above indicators of active part in A. lan-cea fired with bran groups had greater change,with statistical significance (P<0.05). CONCLUSIONS:There are pharmacody-namic differences in the active parts between crude A. lancea and A. lancea fired with bran,the latter one is stronger.
