Pharmacokinetics Study of Puerarin and Puerarin Lobate Extract in Rats
10.6039/j.issn.1001-0408.2016.10.05
- VernacularTitle:葛根素及葛根提取物在大鼠体内的药动学研究
- Author:
Jie ZHAO
;
Chang SU
;
Deguang WEN
;
Jiafu LI
;
Yanxian HU
;
Peng WU
- Publication Type:Journal Article
- Keywords:
Puerarin;
Puerarin lobate extract;
Pharmacokinetics;
Rat
- From:
China Pharmacy
2016;27(10):1311-1314
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the pharmacokinetic characteristics of puerarin and puerarin lobate extract in rats and compare the difference of pharmacokinetic behavior of them. METHODS:24 SD rats were randomly divided into high-dose and low-dose groups of puerarin (300,100 mg/kg) and puerarin lobate extract (equal to 300,100 mg/kg of puerarin). 0.2 ml blood sample were collected from posterior venous plexus of bulbus oculi before intragastric administration and 0.083,0.17,0.33,0.5, 0.67,1,1.5,2,3,4,6,8,10 h after administration,respectively. The pharmacokinetic parameters were calculated by using DAS 3.0 software. RESULTS:Compared with puerarin high-dose group,AUC0-t and cmax of puerarin low-dose group increased sig-nificantly,while CL decreased significantly;MRT0-t of puerarin low-dose group and puerarin lobate extract high-dose and low-dose groups decreased significantly (P<0.01). There was no statistical significance in pharmacokinetic parameters between puerarin lo-bate extract low-dose group and puerarin lobate extract high-dose group (P>0.05). CONCLULSIONS:There is difference in the pharmacokinetic behavior between puerarin and puerarin lobate extract in rats. Some components of puerarin lobate extrats maybe speed up the elimination of puerarin in rats,so as to shorten the average retention time of it.
