Study on Preparation Process of Compound Potentilla discolor Granules
10.6039/j.issn.1001-0408.2016.10.29
- VernacularTitle:复方翻白草颗粒剂的制备工艺研究
- Author:
Helan ZHANG
;
Hongkui LU
;
Chunguang WANG
;
Jiang ZHU
- Publication Type:Journal Article
- Keywords:
Potentilla discolor;
Granules;
Decocting method;
Extraction technology;
Kaempferol;
Quercetin;
Total flavo-noids;
Orthogonal test;
Moldability
- From:
China Pharmacy
2016;27(10):1392-1395
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the extraction technology and forming technology of Compound Potentilla discolor gran-ules. METHODS:The extraction technology was optimized by single factor and orthogonal test with the amount of added water, soaking time,decocting time and decocting times as factors using the comprehensive score of the content of kaempferol,quercetin, and total flavonoids as indexes. Validation test was conducted. The type and ratio of excipients in forming technology were opti-mized by single factor test using comprehensive score of molding rate,soluble rate,moisture absorption rate and angle of repose as indexes. RESULTS:The optimal extraction process was 14-fold water,soaking for 0.5 h,decocting for 3 times,1.0 h each time. The RSDs of kaempferol,quercetin and total flavonoids content in validation test were 1.77%,1.76% and 4.62%(n=5). The ex-cipients of forming technology was the mixture of dextrin and soluble starch (2:1);the molding rate,soluble rate,moisture ab-sorption rate and angle of repose were 94.02%,76%,26% and 25.02 °,respectively. CONCLUSIONS:The optimized extraction technology of Compound P. discolor granules is stable and feasible,and prepared granules have good formability and moisture resis-tance.
