Preparation and Characterization of Andrographolide Phospholipid Compound
10.6039/j.issn.1001-0408.2016.10.34
- VernacularTitle:穿心莲内酯磷脂复合物的制备及表征
- Author:
Fengwei YU
;
Ji NIE
;
Ye YUAN
- Publication Type:Journal Article
- Keywords:
Andrographolide;
Phospholipid compound;
Preparation;
Orthogonal test;
Characterization
- From:
China Pharmacy
2016;27(10):1409-1411
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare andrographolide phospholipid compound,optimize its formulation technology and charac-terizeit. METHODS:Andrographolide phospholipid compound was prepared with solvent method. Using compound rate as index, the effects of reaction solvent,reaction time,reaction temperature,drug concentration,the ratio of reactants and other single fac-tors on compound rate were investigated. The ratio of reactants,reaction temperature and drug concentration were optimized by or-thogonal test and validated. The dissolubilities of andrographolide,andrographolide phospholipid physical mixture and androgra-pholide phospholipid compound in water,soybean oil and Lauroglycol FCC were compared and characterized with UV and DSC. RESULTS:The optimal preparation technology was tetrahydrofuran as reaction solvent,reaction time of 4 h,reaction temperature of 50 ℃,drug concentration of 10 mg/ml,ratio of andrographolide to phospholipid 1:3. The compound rate of andrographolide phospholipid compound was 83.2%(n=3). Compared with raw material and physical mixture,phospholipid compound significant-ly improved the dissolubility of andrographolide in water,soybean oil and Lauroglycol FCC. UV and DSC showed that compound had been prepared. CONCLUSIONS:Andrographolide phospholipid compound is prepared successfully.
