Preparation of Genistein Solid Dispersion and Its Properties Study

VernacularTitle:染料木素固体分散体的制备及其性质研究
Author: Qingjie MENG ; Linlin BAO ; Wujiu PAN ; Weiming WANG ; Hongli WANG
Publication Type:Journal Article
Keywords: Geinstein; Solid dispersion; Dissolution in vitro; FTIR; DSC
From: China Pharmacy 2016;27(10):1406-1408
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To prepare Geinstein (GEN) solid dispersion,and improve the dissolution rate of GEN in vitro. METHODS:Using PVP K30,PEG6000,and PEG4000 as carriers,GEN solid dispersion was prepared by solvent melting meth-od,and its dissolution in vitro was investigated. The structure of the solid dispersion was characterized by FTIR and DSC. RE-SULTS:GEN solid dispersion prepared with PEG4000 as carrier was better than those with other carriers in dissolution,and drug-carrier ratio (1:5) was the best. The results of DSC and FTIR showed that GEN in solid dispersion took amorphous form. CONCLUSIONS:GEN solid dispersion is prepared successfully and significantly improve the dissolution of GEN in vitro.