Recent advances of ELAM-1 in targeted cancer therapy
10.11904/j.issn.1002-3070.2016.05.012
- VernacularTitle:ELAM －1在肿瘤靶向治疗中的应用进展
- Author:
Zhichao ZUO
;
Danke SU
;
Wenjuan DENG
;
Guanqiao JIN
- Publication Type:Journal Article
- Keywords:
ELAM-1;
Tumor;
Targeted therapy
- From:
Practical Oncology Journal
2016;30(5):444-447
- CountryChina
- Language:Chinese
-
Abstract:
Endothelial leukocyte adhesion molecule -1 ( ELAM -1 ) is a member of the cell adhesion molecules,which plays a great role in the distant metastasis of tumor in ligand interactions between sLe (x)and sLe(a).Recently,it becomes a new research hotspot on applying ELAM -1 in targeted cancer therapy.Many studies results show that by regulation of ELAM -1 in biological effects ,such as ELAM-1 and ligand inhibitors , monoclonal antibody ,targeting gene ,and other mediates of the path of blocking therapy ,thereby inhibiting or bloc-king tumor distant metastasis ,so as to achieve the purpose of tumor therapy and improve the prognosis .Therefore , ELAM-1 is expected to exert a critical role in the tumor targeted therapy .In this paper ,the application value of ELAM-1 in tumor related targeted therapy is reviewed .
