The factors analysis on pregnant outcomes between well-differentiated endometrial cancer and atypical endometrial hyperplasia after conservative treat ment
10.11904/j.issn.1002-3070.2016.05.005
- VernacularTitle:高分化子宫内膜癌或非典型子宫内膜增生患者保守治疗后妊娠结局影响因素分析
- Author:
Mingxia WANG
;
Zhiying BAI
;
Li GENG
- Publication Type:Journal Article
- Keywords:
Well -differentiated endometrioid adenocarcinoma;
Atypical endometrial hyperplasia;
Me-droxyprogesterone acetate;
Conservative treatment;
Pregnant outcomes
- From:
Practical Oncology Journal
2016;30(5):409-413
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify factors that might affect establishing pregnancy following conservative treatment by medroxyprogesterone acetate ( MPA)for well -differentiated endometrioid adenocarcinoma ( EC) or a-typical endometrial hyperplasia(AEH).Methods A retrospective study of 65 patients with EC/AEH were divid-ed into a pregnancy group ( n=34 ) and a non -pregnancy group ( n=31 ) .The influent factors on establishing pregnancy were detected by statistical analysis .Results There was no significant difference in clinical character-istics between pregnancy group and non -pregnancy group .There were significantly different between pregnancy group and non-pregnancy in the duration of MPA administration ,the time to disappearance of lesions ,the age of pregnancy permission ,the number of D&C procedures performed ,and endometrial thickness during ovulation ( P<0.05).The multivariate logistic regression analysis identified that the recurrence (OR=2.323,P=0.015),endo-metrial thickness during ovulation (OR=0.283,P <0.001),and age of pregnancy permission (OR=2.524,P=0.039) were significant factors affecting pregnancy outcomes .Conclusion Recurrence, endometrial thickness during ovulation ,and the age of the pregnancy permission were considered to affect pregnant establishment follow -ing conservative treatment with MPA .Assisted reproductive technology immediately after achieving tumor disap-pearance by MPA would therefore be beneficial for patients with disease recurrence ,thin endometrium ,or a higher age of pregnancy permission .
