Effects of Hydrophilic Polymers on the Stability of Self-microemulsifying Drug Delivery Systems
10.6039/j.issn.1001-0408.2016.07.14
- VernacularTitle:亲水性聚合物对自乳化药物传递系统稳定性的影响
- Author:
Boyu JING
;
Xia ZHENG
;
Rui YANG
;
Jia ZHAO
;
Shaojun YU
- Publication Type:Journal Article
- Keywords:
Hydrophilic polymers;
Supersaturable;
Self-microemulsifying drug delivery systems;
Felodipine;
Hydroxypropyl methylcellulose;
Kollidon VA64
- From:
China Pharmacy
2016;27(7):910-912
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of hydrophilic polymers on the stability of self-microemulsifying drug deliv-ery systems (SMEDDS). METHODS:Taking felodipine (FDP) as model drug,the content of FDP was determined by HPLC method. The effects of pure water,0.5% Kollidon VA64,HPMC E5,HPMC K100LV,HPMC K4M,PVP K30 solution,while 0.1%,0.5% and 1.0% HPMC E5 and Kollidon VA64 on residual content of dissolved FDP were determined in SMEDDS. RE-SULTS:The residual contents of dissolved FDP in SMEDDS placed in Kollidon VA64,HPMC E5,HPMC K100LV,PVP K30, HPMC K4M and pure water for 1 h were 92.7%,63.6%,50.2%,46.2%,36.0%and 24.0%,respectively. The order of maintain-ing the supersaturation state was Kollidon VA64>HPMC E5>HPMC K100LV>PVP K30>HPMC K4M>pure water. The residu-al contents of dissolved FDP in SMEDDS placed in 0.1%,0.5%,1% Kollidon VA64 and HPMC E5 and pure water for 1 h were 93.2%,95.1%,96.0% and 48.4%,62.1%,75.1%. CONCLUSIONS:Kollidon VA64 and HPMC E5 can significantly inhibit drug release in SMEDDS and be used as stabilizer of SMEDDS,wherein Kollidon VA64 was better.